Compound Detail
CHEMBL351282
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Basic Information
| ChEMBL ID | CHEMBL351282 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IGTSSQKVYSLTKO-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
337.4
MW (Da)
0.67
ALogP
6
HBA
2
HBD
97.4
PSA (Ų)
0.54
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cAMP-dependent protein kinase (PKA) CHEMBL2094138 | IC50 | 5.7 | 5.7 | 2000.0 | 1 |
| Protein kinase C (PKC) CHEMBL2093867 | IC50 | 4.7 | 4.7 | 20000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cAMP-dependent protein kinase (PKA) | IC50 | = | 2000.0 | nM | 5.7 | Inhibition of cAMP-dependent protein kinase (PKA). | 1992155 |
| Protein kinase C (PKC) | IC50 | = | 20000.0 | nM | 4.7 | Inhibition of protein kinase C (PKC) | 1992155 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1992155 | 10.1021/jm00105a012 | Protein kinase C (PKC) | 1 |
| 1992155 | 10.1021/jm00105a012 | cAMP-dependent protein kinase (PKA) | 1 |
Data from ChEMBL 36 via Core Engine