Compound Detail
CHEMBL3545280
EFATUTAZONE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL3545280 |
| Name | EFATUTAZONE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | JCYNMRJCUYVDBC-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
4
Known Names
8
Indications
Molecular Properties
502.6
MW (Da)
5.04
ALogP
8
HBA
2
HBD
108.5
PSA (Ų)
0.34
QED
2
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Racemic |
Indications
Carcinoma, Non-Small-Cell Lung Colorectal Neoplasms Colorectal Neoplasms Liposarcoma Thyroid Neoplasms Multiple Myeloma Neoplasms Neoplasms
Activity Summary
EC50 2 meas. best 10.42
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor gamma CHEMBL235 | EC50 | 10.42 | 9.71 | 0.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor gamma | EC50 | = | 0.038 | nM | 10.42 | Agonist activity at recombinant human GAL4-DBD fused PPARgamma LBD expressed in ... | 30241907 |
| Peroxisome proliferator-activated receptor gamma | EC50 | = | 1.0 | nM | 9.0 | Transactivation of PPARgamma (unknown origin) transfected in human DRO cells aft... | 30351933 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30241907 | 10.1016/j.bmc.2018.09.006 | Peroxisome proliferator-activated receptor gamma | 2 |
| 30351933 | 10.1021/acs.jmedchem.8b01200 | Peroxisome proliferator-activated receptor gamma | 1 |
| 30351933 | 10.1021/acs.jmedchem.8b01200 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine