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Compound Detail

CHEMBL3546401

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CC1CN=C(Nc2ccc(Cl)c3c2CCC3)C1

Basic Information

ChEMBL ID CHEMBL3546401
Phase Preclinical
Structure Type MOL
InChI Key SMCWDBIRMCZOJC-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

248.8
MW (Da)
3.68
ALogP
2
HBA
1
HBD
24.4
PSA (Ų)
0.81
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C14H17ClN2
MW 248.76
Aromatic Rings 1
Heavy Atoms 17
NP-Likeness -0.30

Activity Summary

Ki 1 meas. best 9.66

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Nischarin
CHEMBL3923
Ki 9.66 9.66 0.2 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Nischarin Ki = 0.22 nM 9.66 I1 Receptor Binding Assay: Binding assays were performed at 37° C. using [125I]L... -

Data from ChEMBL 36 via Core Engine