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Compound Detail

CHEMBL35505

DIHYDRALAZINE
🧪 Phase III
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🧪 Phase III
N/N=c1\[nH][nH]/c(=N\N)c2ccccc12
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL35505
Name DIHYDRALAZINE
Phase Phase III
Structure Type MOL
InChI Key VQKLRVZQQYVIJW-UHFFFAOYSA-N

Known Names

Dihidralazina Dihydralazine NSC-526654
0
Targets
2
Activities
1
Assay Types
0
PK Parameters
20
Publications
3
Known Names
2
Indications

Molecular Properties

190.2
MW (Da)
-0.96
ALogP
4
HBA
4
HBD
108.3
PSA (Ų)
0.32
QED
0
Ro5 Violations
0
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Achiral

Flags

Natural Product
USAN Stem -dralazine; -lazine

Extended Properties

Molecular Formula C8H10N6
MW 190.21
Aromatic Rings 2
Heavy Atoms 14
NP-Likeness -0.29

Indications

Aortic Valve Stenosis Hypertension

ATC Classification

C02DB01
dihydralazine
Level 1: CARDIOVASCULAR SYSTEM
Level 2: ANTIHYPERTENSIVES

Activity Summary

IC50 2 meas.

Literature References

PubMed DOI Target Context # Activities
15646539 10.1016/s0399-8320(04)95062-2 Unchecked 11
15646539 10.1016/s0399-8320(04)95062-2 NON-PROTEIN TARGET 8
7205877 10.1021/jm00133a013 Rattus norvegicus 5
6854582 10.1021/jm00360a004 Homo sapiens 3
2795599 10.1021/jm00130a009 Rattus norvegicus 3
20014752 10.1021/tx900326k Hepatotoxicity 3
3783580 10.1021/jm00161a010 Rattus norvegicus 3
37468498 10.1038/s41467-023-40064-9 Thromboxane A2 receptor 2
6854582 10.1021/jm00360a004 Rattus norvegicus 2
37468498 10.1038/s41467-023-40064-9 Prostaglandin G/H synthase 1 2
37468498 10.1038/s41467-023-40064-9 Muscarinic acetylcholine receptor M1 2
- 10.6019/CHEMBL4651402 SARS-CoV-2 2
37468498 10.1038/s41467-023-40064-9 Alpha-1A adrenergic receptor 2
21965623 10.1124/dmd.111.040758 Bile salt export pump 2
20020916 10.1080/15376510701857262 Phospholipidosis 1
35820623 10.1016/j.bmcl.2022.128883 Aspartate aminotransferase, cytoplasmic 1
22961681 10.1124/dmd.112.047068 Bile salt export pump 1
16248836 10.2174/138920005774330639 Cytochrome P450 3A4 1
6492077 10.1021/jm00377a016 Rattus norvegicus 1
6492077 10.1021/jm00377a016 Felis catus 1

Data from ChEMBL 36 via Core Engine