Compound Detail
CHEMBL357683
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Basic Information
| ChEMBL ID | CHEMBL357683 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IYVMXMJAYLDUHH-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
242.1
MW (Da)
2.84
ALogP
2
HBA
1
HBD
33.1
PSA (Ų)
0.77
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 5.43
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | EC50 | 5.43 | 5.43 | 3700.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | EC50 | = | 3700.0 | nM | 5.43 | Reversal of Zn-induced human soluble amyloid beta (1 to 42) aggregation after 30... | 26396692 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26396692 | 10.1021/acsmedchemlett.5b00281 | SH-SY5Y | 2 |
| 7381845 | 10.1021/jm00178a018 | Aspergillus niger | 1 |
| 7381845 | 10.1021/jm00178a018 | Aspergillus oryzae | 1 |
| 7381845 | 10.1021/jm00178a018 | Trichoderma viride | 1 |
| 7381845 | 10.1021/jm00178a018 | Trichophyton benhamiae | 1 |
| 7381845 | 10.1021/jm00178a018 | Albifimbria verrucaria | 1 |
| 26396692 | 10.1021/acsmedchemlett.5b00281 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine