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Compound Detail

CHEMBL358150

ETOFIBRATE
🧪 Phase II
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🧪 Phase II
CC(C)(Oc1ccc(Cl)cc1)C(=O)OCCOC(=O)c1cccnc1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL358150
Name ETOFIBRATE
Phase Phase II
Structure Type MOL
InChI Key XXRVYAFBUDSLJX-UHFFFAOYSA-N

Known Names

Etofibrate Etofibrato
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
20
Publications
2
Known Names
1
Indications

Molecular Properties

363.8
MW (Da)
3.29
ALogP
6
HBA
0
HBD
74.7
PSA (Ų)
0.55
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Achiral

Flags

Natural Product
USAN Stem -fibrate

Extended Properties

Molecular Formula C18H18ClNO5
MW 363.80
Aromatic Rings 2
Heavy Atoms 25
NP-Likeness -0.81

Indications

Cardiovascular Diseases

ATC Classification

C10AB09
etofibrate
Level 1: CARDIOVASCULAR SYSTEM
Level 2: LIPID MODIFYING AGENTS

Literature References

PubMed DOI Target Context # Activities
15646539 10.1016/s0399-8320(04)95062-2 Unchecked 11
15646539 10.1016/s0399-8320(04)95062-2 NON-PROTEIN TARGET 8
- 10.6019/CHEMBL4495565 SARS-CoV-2 4
34547896 10.1021/acs.jmedchem.1c00823 Transthyretin 4
37468498 10.1038/s41467-023-40064-9 Nuclear receptor subfamily 1 group I member 2 3
37468498 10.1038/s41467-023-40064-9 Progesterone receptor 2
- 10.6019/CHEMBL4495564 Replicase polyprotein 1ab 2
37468498 10.1038/s41467-023-40064-9 Gamma-aminobutyric acid receptor subunit alpha-1 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
37468498 10.1038/s41467-023-40064-9 Alpha-2A adrenergic receptor 2
37468498 10.1038/s41467-023-40064-9 Cannabinoid receptor 1 2
37468498 10.1038/s41467-023-40064-9 Peroxisome proliferator-activated receptor gamma 2
37468498 10.1038/s41467-023-40064-9 Muscarinic acetylcholine receptor M2 2
37468498 10.1038/s41467-023-40064-9 Alpha-1A adrenergic receptor 2
37468498 10.1038/s41467-023-40064-9 Beta-1 adrenergic receptor 2
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 2B 2
37468498 10.1038/s41467-023-40064-9 Androgen receptor 2
37468498 10.1038/s41467-023-40064-9 Beta-2 adrenergic receptor 2
37468498 10.1038/s41467-023-40064-9 Peroxisome proliferator-activated receptor alpha 2
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 2A 2

Data from ChEMBL 36 via Core Engine