Compound Detail
CHEMBL3609016
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Basic Information
| ChEMBL ID | CHEMBL3609016 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KRRJDGLUFFFYHX-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
446.2
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.48
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| C-X-C chemokine receptor type 1 CHEMBL4029 | IC50 | 8.48 | 8.48 | 3.3 | 1 |
| C-X-C chemokine receptor type 2 CHEMBL2434 | IC50 | 7.68 | 7.68 | 21.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| C-X-C chemokine receptor type 1 | IC50 | = | 3.3 | nM | 8.48 | Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed ... | 26248802 |
| C-X-C chemokine receptor type 2 | IC50 | = | 21.0 | nM | 7.68 | Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed ... | 26248802 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26248802 | 10.1016/j.bmcl.2015.07.090 | C-X-C chemokine receptor type 1 | 1 |
| 26248802 | 10.1016/j.bmcl.2015.07.090 | C-X-C chemokine receptor type 2 | 1 |
Data from ChEMBL 36 via Core Engine