Compound Detail
CHEMBL3612488
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Basic Information
| ChEMBL ID | CHEMBL3612488 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OYSNJOXPTBUMBO-DNTJNYDQSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
433.8
MW (Da)
2.94
ALogP
7
HBA
0
HBD
89.2
PSA (Ų)
0.35
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.11
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | IC50 | 5.11 | 5.11 | 7791.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 7791.0 | nM | 5.11 | Inhibition of FLT3 (unknown origin) using biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu... | 26349627 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26349627 | 10.1016/j.bmc.2015.08.035 | CDK9/cyclin T1 | 1 |
| 26349627 | 10.1016/j.bmc.2015.08.035 | Cyclin-dependent kinase 7 | 1 |
| 26349627 | 10.1016/j.bmc.2015.08.035 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 1 |
| 26349627 | 10.1016/j.bmc.2015.08.035 | Receptor-type tyrosine-protein kinase FLT3 | 1 |
Data from ChEMBL 36 via Core Engine