Compound Detail
CHEMBL3622170
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL3622170 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YZCIZVFQKAHBPW-FXAWDEMLSA-N |
2
Targets
2
Activities
1
Assay Types
1
PK Parameters
3
Publications
0
Known Names
Molecular Properties
449.6
MW (Da)
3.10
ALogP
7
HBA
0
HBD
81.6
PSA (Ų)
0.61
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 8.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucose-dependent insulinotropic receptor CHEMBL5263 | EC50 | 8.85 | 8.85 | 1.4 | 1 |
| Glucose-dependent insulinotropic receptor CHEMBL5652 | EC50 | 8.35 | 8.35 | 4.5 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 0.6 | hr | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glucose-dependent insulinotropic receptor | EC50 | = | 1.4 | nM | 8.85 | Agonist activity at mouse GPR119 by cAMP assay | 26288697 |
| Glucose-dependent insulinotropic receptor | EC50 | = | 4.5 | nM | 8.35 | Agonist activity at human GPR119 expressed in CHO cells by cAMP assay | 26288697 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26288697 | 10.1021/acsmedchemlett.5b00207 | Glucose-dependent insulinotropic receptor | 4 |
| 26288697 | 10.1021/acsmedchemlett.5b00207 | No relevant target | 2 |
| 26288697 | 10.1021/acsmedchemlett.5b00207 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine