Compound Detail
CHEMBL3632741
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Basic Information
| ChEMBL ID | CHEMBL3632741 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZGSDVEBXWRCHHZ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
317.4
MW (Da)
3.89
ALogP
5
HBA
2
HBD
75.1
PSA (Ų)
0.77
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 6.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| MAP kinase-interacting serine/threonine-protein kinase 2 CHEMBL4204 | Ki | 6.3 | 6.3 | 500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| MAP kinase-interacting serine/threonine-protein kinase 2 | Ki | = | 500.0 | nM | 6.3 | Inhibition of human Mnk2a using TAMRA-labeled eIF4E peptide as substrate incubat... | 26408454 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26408454 | 10.1016/j.ejmech.2015.09.008 | MAP kinase-interacting serine/threonine-protein kinase 2 | 1 |
| 26408454 | 10.1016/j.ejmech.2015.09.008 | MV4-11 | 1 |
| 26408454 | 10.1016/j.ejmech.2015.09.008 | Mus musculus | 1 |
| 26408454 | 10.1016/j.ejmech.2015.09.008 | MAP kinase-interacting serine/threonine-protein kinase 1 | 1 |
Data from ChEMBL 36 via Core Engine