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Compound Detail

CHEMBL363988

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C/C(=C\[C@H](C(C)C)N(C)C(=O)[C@@H](NC(=O)[C@@H](N)C(C)(C)c1ccccc1C)C(C)(C)C)C(=O)O

Basic Information

ChEMBL ID CHEMBL363988
Phase Preclinical
Structure Type MOL
InChI Key WABDMPFDIFLBNY-QSTMGXEESA-N
2
Targets
6
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

473.7
MW (Da)
3.64
ALogP
4
HBA
3
HBD
112.7
PSA (Ų)
0.47
QED
0
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H43N3O4
MW 473.66
Aromatic Rings 1
Heavy Atoms 34
NP-Likeness 1.19

Activity Summary

IC50 6 meas. best 9.05

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
KB 3-1
CHEMBL614590
IC50 9.05 8.4525 0.9 4
KB
CHEMBL398
IC50 7.25 6.775 56.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
15454219 10.1016/j.bmcl.2004.08.024 KB 3-1 4
15454219 10.1016/j.bmcl.2004.08.024 Bos taurus 4
15454219 10.1016/j.bmcl.2004.08.024 KB 2

Data from ChEMBL 36 via Core Engine