Compound Detail
CHEMBL3644732
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Cc1nc2cnc3ccc(C#CCNC(=O)c4cccn([C@@H](C)c5ccc(F)c(F)c5)c4=O)cc3c2n1[C@H]1CC[C@@H](N(C)C)CC1
Basic Information
| ChEMBL ID | CHEMBL3644732 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VKFOQIFPQVNLLW-WDDWZANVSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
622.7
MW (Da)
5.77
ALogP
7
HBA
1
HBD
85.0
PSA (Ų)
0.24
QED
2
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 9.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 3-phosphoinositide-dependent protein kinase 1 CHEMBL2534 | IC50 | 9.0 | 9.0 | 1.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 3-phosphoinositide-dependent protein kinase 1 | IC50 | = | 1.0 | nM | 9.0 | Kinase Assay: Recombinant human PDK1 enzyme (aa 52-556) linked at its N-terminal... | - |
Data from ChEMBL 36 via Core Engine