Compound Detail
CHEMBL365300
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Basic Information
| ChEMBL ID | CHEMBL365300 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HOZRKIFTGIPXPR-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
469.9
MW (Da)
4.60
ALogP
7
HBA
0
HBD
96.6
PSA (Ų)
0.39
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 7.72 | 7.72 | 19.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 19.0 | nM | 7.72 | Inhibition of [3H]FPP incorporation into biotin-linked K-ras decapeptide (CVIM) ... | 15324873 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15324873 | 10.1016/j.bmcl.2004.07.004 | Unchecked | 1 |
| 15324873 | 10.1016/j.bmcl.2004.07.004 | Geranylgeranyl transferase type I | 1 |
| 15324873 | 10.1016/j.bmcl.2004.07.004 | Protein farnesyltransferase | 1 |
Data from ChEMBL 36 via Core Engine