Compound Detail
CHEMBL3675778
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Basic Information
| ChEMBL ID | CHEMBL3675778 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JSNWHSDKJSOXET-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
279.2
MW (Da)
3.52
ALogP
3
HBA
1
HBD
50.8
PSA (Ų)
0.78
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Core-binding factor subunit beta CHEMBL1615386 | IC50 | 6.0 | 6.0 | 1000.0 | 1 |
| Runt-related transcription factor 1 CHEMBL1615385 | IC50 | 5.5 | 5.5 | 3190.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Core-binding factor subunit beta | IC50 | = | 1000.0 | nM | 6.0 | FRET Assay: We have developed effective assays to monitor the inhibition of CBFβ... | - |
| Runt-related transcription factor 1 | IC50 | = | 3190.0 | nM | 5.5 | Fluorescence Resonance Energy Transfer (FRET) Assay: FRET assay can be used to e... | - |
Data from ChEMBL 36 via Core Engine