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Compound Detail

CHEMBL3689064

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Cc1c(C(F)(F)F)nn(-c2cccc(Cl)c2)c1CNC(=O)Cc1cccc(F)c1

Basic Information

ChEMBL ID CHEMBL3689064
Phase Preclinical
Structure Type MOL
InChI Key YNHVUIOJESEHFI-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

425.8
MW (Da)
4.85
ALogP
3
HBA
1
HBD
46.9
PSA (Ų)
0.59
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H16ClF4N3O
MW 425.81
Aromatic Rings 3
Heavy Atoms 29
NP-Likeness -1.96

Activity Summary

Ki 1 meas. best 6.95

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Transient receptor potential cation channel subfamily V member 1
CHEMBL4794
Ki 6.95 6.95 112.0 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine