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Compound Detail

CHEMBL3694401

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COc1cccc(F)c1-c1cc(NC(=O)C2CCCNC2)ncn1

Basic Information

ChEMBL ID CHEMBL3694401
Phase Preclinical
Structure Type MOL
InChI Key XAMCFOQPATUPRC-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

330.4
MW (Da)
2.23
ALogP
5
HBA
2
HBD
76.1
PSA (Ų)
0.90
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C17H19FN4O2
MW 330.36
Aromatic Rings 2
Heavy Atoms 24
NP-Likeness -1.32

Activity Summary

IC50 1 meas. best 10.41

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Cyclin-dependent kinase 9
CHEMBL3116
IC50 10.41 10.41 0.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Cyclin-dependent kinase 9 IC50 = 0.039 nM 10.41 In Vitro Kinase Inhibition Assays: All kinase assays were performed in 96-well F... -

Data from ChEMBL 36 via Core Engine