Compound Detail
CHEMBL370413
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Basic Information
| ChEMBL ID | CHEMBL370413 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YQLFZSHYGLGIRJ-QGZVFWFLSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
480.4
MW (Da)
3.66
ALogP
6
HBA
1
HBD
74.0
PSA (Ų)
0.61
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.11
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase CHEMBL1827 | IC50 | 8.11 | 8.11 | 7.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase | IC50 | = | 7.8 | nM | 8.11 | Inhibition of human phosphodiesterase 5 | 15837326 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15837326 | 10.1016/j.bmcl.2005.02.083 | cGMP-specific 3',5'-cyclic phosphodiesterase | 1 |
| 15837326 | 10.1016/j.bmcl.2005.02.083 | Phosphodiesterase, PDE1/PDE5 | 1 |
| 15837326 | 10.1016/j.bmcl.2005.02.083 | Phosphodiesterases; PDE5 & PDE6 | 1 |
Data from ChEMBL 36 via Core Engine