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Compound Detail

CHEMBL372435

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CN1[C@H](/C=C/c2ccccc2)CCC[C@@H]1/C=C/c1ccccc1

Basic Information

ChEMBL ID CHEMBL372435
Phase Preclinical
Structure Type MOL
InChI Key BCHCCPODJPHTTL-GKQVGWSZSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

303.4
MW (Da)
5.27
ALogP
1
HBA
0
HBD
3.2
PSA (Ų)
0.74
QED
1
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H25N
MW 303.45
Aromatic Rings 2
Heavy Atoms 23
NP-Likeness 0.39

Activity Summary

Ki 2 meas. best 5.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Synaptic vesicular amine transporter
CHEMBL4828
Ki 5.0 5.0 9880.0 1
Neuronal acetylcholine receptor; alpha4/beta2
CHEMBL1907596
Ki 4.94 4.94 11600.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
16107155 10.1021/jm0501228 Unchecked 2
16107155 10.1021/jm0501228 Neuronal acetylcholine receptor; alpha4/beta2 1
16107155 10.1021/jm0501228 Neuronal acetylcholine receptor subunit alpha-7 1
16107155 10.1021/jm0501228 Synaptic vesicular amine transporter 1

Data from ChEMBL 36 via Core Engine