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Compound Detail

CHEMBL373855

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CSc1cn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)[nH]c1=O

Basic Information

ChEMBL ID CHEMBL373855
Phase Preclinical
Structure Type MOL
InChI Key NQJYWLBQAUXGGI-SHYZEUOFSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

274.3
MW (Da)
-1.10
ALogP
7
HBA
3
HBD
104.5
PSA (Ų)
0.60
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C10H14N2O5S
MW 274.30
Aromatic Rings 1
Heavy Atoms 18
NP-Likeness 0.71

Activity Summary

Ki 2 meas. best 4.3

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Thymidine kinase, cytosolic
CHEMBL4022
Ki 4.3 4.3 50000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Thymidine kinase, cytosolic Ki = 50000.0 nM 4.3 Competitive inhibition against rat cytoplasmic Thymidine kinase 7097717

Literature References

PubMed DOI Target Context # Activities
7097717 10.1021/jm00348a007 Thymidine kinase 2 2
7097717 10.1021/jm00348a007 Thymidine kinase, cytosolic 2
7097717 10.1021/jm00348a007 Unchecked 1
17341060 10.1021/jm061445m ADMET 1

Data from ChEMBL 36 via Core Engine