Compound Detail
CHEMBL3740225
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Basic Information
| ChEMBL ID | CHEMBL3740225 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GOGBXMHYECRFIZ-CRXSXSLSSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
352.5
MW (Da)
4.19
ALogP
2
HBA
1
HBD
32.3
PSA (Ų)
0.88
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 11-beta-hydroxysteroid dehydrogenase 1 CHEMBL4235 | IC50 | 6.0 | 6.0 | 1000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 11-beta-hydroxysteroid dehydrogenase 1 | IC50 | = | 1000.0 | nM | 6.0 | Inhibition of 11beta-HSD1 in human liver microsomes assessed as conversion of [3... | 26596711 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26596711 | 10.1016/j.bmc.2015.11.004 | 11-beta-hydroxysteroid dehydrogenase 1 | 2 |
Data from ChEMBL 36 via Core Engine