Compound Detail
CHEMBL3740931
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Basic Information
| ChEMBL ID | CHEMBL3740931 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WOVXQOUTTUUVFV-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
280.3
MW (Da)
2.25
ALogP
4
HBA
4
HBD
91.2
PSA (Ų)
0.44
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.04
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Urokinase-type plasminogen activator CHEMBL3286 | IC50 | 5.04 | 5.04 | 9040.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Urokinase-type plasminogen activator | IC50 | = | 9040.0 | nM | 5.04 | Inhibition of human uPA using pyro-Glu-Gly-Arg-pNA as substrate assessed as para... | 26575094 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26575094 | 10.1021/acs.jmedchem.5b01171 | Urokinase-type plasminogen activator | 1 |
| 26575094 | 10.1021/acs.jmedchem.5b01171 | Coagulation factor VII | 1 |
| 26575094 | 10.1021/acs.jmedchem.5b01171 | Prothrombin | 1 |
| 26575094 | 10.1021/acs.jmedchem.5b01171 | Tissue-type plasminogen activator | 1 |
| 26575094 | 10.1021/acs.jmedchem.5b01171 | Coagulation factor X | 1 |
| 26575094 | 10.1021/acs.jmedchem.5b01171 | Plasminogen | 1 |
| 26575094 | 10.1021/acs.jmedchem.5b01171 | Plasma kallikrein | 1 |
| 26575094 | 10.1021/acs.jmedchem.5b01171 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine