Compound Detail
CHEMBL374463
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Basic Information
| ChEMBL ID | CHEMBL374463 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RCIIYIDXACVAQP-VIFPVBQESA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
290.7
MW (Da)
2.46
ALogP
2
HBA
1
HBD
32.3
PSA (Ų)
0.80
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 6.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2C CHEMBL225 | Ki | 6.05 | 6.05 | 900.0 | 1 |
| 5-hydroxytryptamine receptor 2A CHEMBL224 | Ki | 5.98 | 5.98 | 1040.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2C | Ki | = | 900.0 | nM | 6.05 | Displacement of [125I]DOI from human recombinant 5HT2C expressed in HEK293E cell... | 17315987 |
| 5-hydroxytryptamine receptor 2A | Ki | = | 1040.0 | nM | 5.98 | Displacement of [125I]DOI from human recombinant 5HT2A expressed in HEK293E cell... | 17315987 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17315987 | 10.1021/jm0612968 | 5-hydroxytryptamine receptor 2C | 3 |
| 17315987 | 10.1021/jm0612968 | 5-hydroxytryptamine receptor 2A | 3 |
| 17315987 | 10.1021/jm0612968 | 5-hydroxytryptamine receptor 2B | 3 |
Data from ChEMBL 36 via Core Engine