Compound Detail
CHEMBL3746993
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Basic Information
| ChEMBL ID | CHEMBL3746993 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GUEJPHBZVNDVDW-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
466.0
MW (Da)
5.85
ALogP
7
HBA
1
HBD
72.8
PSA (Ų)
0.34
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 11.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A CHEMBL4409 | Ki | 11.0 | 11.0 | 0.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | Ki | = | 0.01 | nM | 11.0 | Inhibition of PDE10A (unknown origin) by IMAP assay | 26602277 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26602277 | 10.1016/j.bmcl.2015.11.013 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 1 |
Data from ChEMBL 36 via Core Engine