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Compound Detail

CHEMBL3747105

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CC[N+]1(CC)CCN(c2ccc(C#N)cc2)CC1.[I-]

Basic Information

ChEMBL ID CHEMBL3747105
Phase Preclinical
Structure Type MOL
InChI Key CODZVLVSXQWNPO-UHFFFAOYSA-M
Parent Compound CHEMBL3747912
Active Moiety CHEMBL3747912
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

244.4
MW (Da)
2.23
ALogP
2
HBA
0
HBD
27.0
PSA (Ų)
0.76
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H22IN3
MW 371.27
Aromatic Rings 1
Heavy Atoms 18
NP-Likeness -1.11

Activity Summary

EC50 2 meas. best 6.43

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Neuronal acetylcholine receptor subunit alpha-9
CHEMBL2184
EC50 6.43 6.43 368.0 1
Neuronal acetylcholine receptor; alpha9/alpha10
CHEMBL2109238
EC50 5.59 5.59 2570.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
26707847 10.1016/j.bmc.2015.12.017 Neuronal acetylcholine receptor subunit alpha-7 4
38748608 10.1021/acs.jmedchem.3c02429 Neuronal acetylcholine receptor; alpha9/alpha10 2
38748608 10.1021/acs.jmedchem.3c02429 Neuronal acetylcholine receptor subunit alpha-9 1

Data from ChEMBL 36 via Core Engine