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Compound Detail

CHEMBL376080

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COC(=O)[C@H](NC(=O)CN1CCOCCOCCN(CC(=O)N[C@@H](C(=O)OC)c2ccccc2)CCOCCOCC1)c1ccccc1

Basic Information

ChEMBL ID CHEMBL376080
Phase Preclinical
Structure Type MOL
InChI Key GXHMDNUDJASZBX-ROJLCIKYSA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

672.8
MW (Da)
0.73
ALogP
12
HBA
2
HBD
154.2
PSA (Ų)
0.34
QED
2
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C34H48N4O10
MW 672.78
Aromatic Rings 2
Heavy Atoms 48
NP-Likeness -0.71

Literature References

PubMed DOI Target Context # Activities
17300184 10.1021/jm061162u HeLa 1
17300184 10.1021/jm061162u MIA PaCa-2 1
17300184 10.1021/jm061162u NCI-H460 1
17300184 10.1021/jm061162u SW-620 1
17300184 10.1021/jm061162u MCF7 1

Data from ChEMBL 36 via Core Engine