Compound Detail
CHEMBL376470
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Basic Information
| ChEMBL ID | CHEMBL376470 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LESGKWOTXMFHMB-VPHXOMNUSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
276.4
MW (Da)
3.38
ALogP
3
HBA
1
HBD
41.5
PSA (Ų)
0.92
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.7
Ki 1 meas. best 7.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 11-beta-hydroxysteroid dehydrogenase 1 CHEMBL4235 | IC50 | 7.7 | 7.7 | 20.0 | 1 |
| 11-beta-hydroxysteroid dehydrogenase 1 CHEMBL4235 | Ki | 7.3 | 7.3 | 50.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 11-beta-hydroxysteroid dehydrogenase 1 | IC50 | = | 20.0 | nM | 7.7 | Inhibition of human 11beta-HSD1 over expressed in CHO cells by whole cell assay | 17266194 |
| 11-beta-hydroxysteroid dehydrogenase 1 | Ki | = | 50.0 | nM | 7.3 | Displacement of [3H]cortisone from human recombinant 11beta-HSD1 by SPA | 17266194 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17266194 | 10.1021/jm061214f | 11-beta-hydroxysteroid dehydrogenase 1 | 2 |
Data from ChEMBL 36 via Core Engine