Compound Detail
CHEMBL378179
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Basic Information
| ChEMBL ID | CHEMBL378179 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GTXNQXVWASTZFN-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
290.4
MW (Da)
2.38
ALogP
3
HBA
2
HBD
72.2
PSA (Ų)
0.86
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 6.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 6 CHEMBL3371 | Ki | 6.64 | 6.64 | 230.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 6 | Ki | = | 230.0 | nM | 6.64 | Binding affinity to human 5HT6 receptor in HEK293 cells by radioligand binding a... | 16913710 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16913710 | 10.1021/jm060469q | 5-hydroxytryptamine receptor 6 | 1 |
Data from ChEMBL 36 via Core Engine