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Compound Detail

CHEMBL379546

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CO/N=C(/CCN1CCC(c2cccc[n+]2[O-])CC1)c1ccc(Cl)cc1

Basic Information

ChEMBL ID CHEMBL379546
Phase Preclinical
Structure Type MOL
InChI Key UXZSXFCPMYKUSL-QOCHGBHMSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

373.9
MW (Da)
3.59
ALogP
4
HBA
0
HBD
51.8
PSA (Ų)
0.34
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H24ClN3O2
MW 373.88
Aromatic Rings 2
Heavy Atoms 26
NP-Likeness -1.04

Activity Summary

EC50 1 meas. best 7.33

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(4) dopamine receptor
CHEMBL219
EC50 7.33 7.33 46.4 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
16913699 10.1021/jm060279f D(2) dopamine receptor 2
16913699 10.1021/jm060279f D(4) dopamine receptor 2

Data from ChEMBL 36 via Core Engine