Compound Detail
CHEMBL3797390
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Basic Information
| ChEMBL ID | CHEMBL3797390 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OVNPZKKOYABVCD-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
379.8
MW (Da)
3.12
ALogP
5
HBA
2
HBD
101.2
PSA (Ų)
0.73
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 8.9
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 CHEMBL2736 | EC50 | 8.9 | 7.4 | 1.2 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 | EC50 | = | 1.25 | nM | 8.9 | Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO ... | 27131990 |
| Metabotropic glutamate receptor 4 | EC50 | = | 1258.93 | nM | 5.9 | Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO ... | 27131990 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27131990 | 10.1016/j.bmcl.2016.04.041 | Metabotropic glutamate receptor 4 | 3 |
Data from ChEMBL 36 via Core Engine