Compound Detail
CHEMBL3798239
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Basic Information
| ChEMBL ID | CHEMBL3798239 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NPWXHVJMCNCZDA-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
355.8
MW (Da)
3.46
ALogP
6
HBA
2
HBD
103.0
PSA (Ų)
0.74
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 8.87
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 CHEMBL2736 | EC50 | 8.87 | 7.37 | 1.4 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 | EC50 | = | 1.35 | nM | 8.87 | Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO ... | 27131990 |
| Metabotropic glutamate receptor 4 | EC50 | = | 1348.96 | nM | 5.87 | Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO ... | 27131990 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27131990 | 10.1016/j.bmcl.2016.04.041 | Metabotropic glutamate receptor 4 | 3 |
Data from ChEMBL 36 via Core Engine