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Compound Detail

CHEMBL3799415

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C[C@H]1O[C@@H](n2cnc3c(N)nc(N=[N+]=[N-])nc32)[C@H](O)[C@@H]1O

Basic Information

ChEMBL ID CHEMBL3799415
Phase Preclinical
Structure Type MOL
InChI Key YMMCICZPJVZFLX-UUOKFMHZSA-N
0
Targets
5
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names

Molecular Properties

292.3
MW (Da)
-0.01
ALogP
9
HBA
3
HBD
168.1
PSA (Ų)
0.40
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C10H12N8O3
MW 292.26
Aromatic Rings 2
Heavy Atoms 21
NP-Likeness 1.05

Activity Summary

IC50 5 meas.

Literature References

PubMed DOI Target Context # Activities
28284860 10.1016/j.bmc.2017.02.016 Unchecked 3
27156774 10.1016/j.bmcl.2016.04.053 Plasmodium falciparum 1
27156774 10.1016/j.bmcl.2016.04.053 L6 1
27156774 10.1016/j.bmcl.2016.04.053 Unchecked 1
28284860 10.1016/j.bmc.2017.02.016 Trypanosoma brucei rhodesiense 1
28284860 10.1016/j.bmc.2017.02.016 Trypanosoma cruzi 1
28284860 10.1016/j.bmc.2017.02.016 Leishmania donovani 1

Data from ChEMBL 36 via Core Engine