Compound Detail
CHEMBL3799939
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CC(C)(O)CC(=O)N1CC[C@H]2CN(c3cccc4c3cnn4-c3ccccc3F)C(=O)[C@H]21
Basic Information
| ChEMBL ID | CHEMBL3799939 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VGPVZPALXCWXDX-NYHFZMIOSA-N |
2
Targets
2
Activities
1
Assay Types
2
PK Parameters
3
Publications
0
Known Names
Molecular Properties
436.5
MW (Da)
2.89
ALogP
5
HBA
1
HBD
78.7
PSA (Ų)
0.68
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.87
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sodium channel protein type 9 subunit alpha CHEMBL4296 | IC50 | 5.87 | 5.87 | 1350.0 | 1 |
| Sodium channel protein type 5 subunit alpha CHEMBL1980 | IC50 | 4.79 | 4.79 | 16400.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 58.33 | mL.min-1.kg-1 | Homo sapiens |
| CL | 98.33 | mL.min-1.kg-1 | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sodium channel protein type 9 subunit alpha | IC50 | = | 1350.0 | nM | 5.87 | Inhibition of recombinant human Nav1.7 expressed in HEK293F cells preincubated f... | 27015369 |
| Sodium channel protein type 5 subunit alpha | IC50 | = | 16400.0 | nM | 4.79 | Inhibition of human Nav1.5 expressed in HEK293 cells by whole cell-patch clamp m... | 27015369 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27015369 | 10.1021/acs.jmedchem.6b00063 | Sodium channel protein type 9 subunit alpha | 2 |
| 27015369 | 10.1021/acs.jmedchem.6b00063 | Liver microsome | 2 |
| 27015369 | 10.1021/acs.jmedchem.6b00063 | Sodium channel protein type 5 subunit alpha | 1 |
Data from ChEMBL 36 via Core Engine