Compound Detail
CHEMBL3818672
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Basic Information
| ChEMBL ID | CHEMBL3818672 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MDVFITMPFHDRBZ-JLHYYAGUSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
371.9
MW (Da)
5.42
ALogP
2
HBA
2
HBD
66.4
PSA (Ų)
0.48
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 5.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Potassium channel subfamily K member 2 CHEMBL2321615 | EC50 | 5.52 | 5.52 | 3000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Potassium channel subfamily K member 2 | EC50 | = | 3000.0 | nM | 5.52 | Activation of human TREK1 expressed in CHO cells assessed as increase in channel... | 26588045 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26588045 | 10.1021/acs.jmedchem.5b00671 | Potassium channel subfamily K member 2 | 3 |
| 33784097 | 10.1021/acs.jmedchem.0c02129 | Transient receptor potential cation channel subfamily M member 2 | 1 |
Data from ChEMBL 36 via Core Engine