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Compound Detail

CHEMBL381913

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CC(C)(CN1C(=O)c2cccc3cccc(c23)C1=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC#CCN1OCCC1=O.[Br-].[Br-]

Basic Information

ChEMBL ID CHEMBL381913
Phase Preclinical
Structure Type MOL
InChI Key WBRQDDBRCQMIFG-UHFFFAOYSA-L
Parent Compound CHEMBL1184985
Active Moiety CHEMBL1184985
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

576.8
MW (Da)
4.34
ALogP
4
HBA
0
HBD
66.9
PSA (Ų)
0.15
QED
1
Ro5 Violations
13
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C34H48Br2N4O4
MW 736.59
Aromatic Rings 2
Heavy Atoms 42
NP-Likeness -0.11

Activity Summary

EC50 1 meas. best 8.63

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M2
CHEMBL4781
EC50 8.63 8.63 2.3 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
16392821 10.1021/jm050769s Muscarinic acetylcholine receptor M2 4
16392821 10.1021/jm050769s Muscarinic acetylcholine receptor M3 4
16392821 10.1021/jm050769s Muscarinic acetylcholine receptor M1 2

Data from ChEMBL 36 via Core Engine