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Compound Detail

CHEMBL382672

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Cn1cnc(NCCc2ccc3c(c2)OCO3)c1-c1nnc(Nc2ccc(Cl)cc2)o1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL382672
Phase Preclinical
Structure Type MOL
InChI Key IKGJNEBAOUMBHM-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
16
Publications
0
Known Names

Molecular Properties

438.9
MW (Da)
4.25
ALogP
9
HBA
2
HBD
99.3
PSA (Ų)
0.44
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H19ClN6O3
MW 438.88
Aromatic Rings 4
Heavy Atoms 31
NP-Likeness -1.07

Activity Summary

IC50 2 meas. best 6.02

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Vascular endothelial growth factor receptor 2
CHEMBL279
 IC50 6.02 6.02 960.0 1
Vascular endothelial growth factor receptor 1
CHEMBL1868
 IC50 5.83 5.83 1470.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Vascular endothelial growth factor receptor 2 IC50 = 960.0 nM 6.02 Inhibition of VEGFR2 by enzymatic assay 16321531
Vascular endothelial growth factor receptor 1 IC50 = 1470.0 nM 5.83 Inhibition of VEGFR1 by enzymatic assay 16321531

Literature References

PubMed DOI Target Context # Activities
16321531 10.1016/j.bmcl.2005.11.033 Vascular endothelial growth factor receptor 2 2
16321531 10.1016/j.bmcl.2005.11.033 Vascular endothelial growth factor receptor 1 1
16321531 10.1016/j.bmcl.2005.11.033 Insulin-like growth factor 1 receptor 1
16321531 10.1016/j.bmcl.2005.11.033 Insulin receptor 1
16321531 10.1016/j.bmcl.2005.11.033 Fibroblast growth factor receptor 1 1
16321531 10.1016/j.bmcl.2005.11.033 Receptor-type tyrosine-protein kinase FLT3 1
16321531 10.1016/j.bmcl.2005.11.033 Epidermal growth factor receptor 1
16321531 10.1016/j.bmcl.2005.11.033 Receptor tyrosine-protein kinase erbB-2 1
16321531 10.1016/j.bmcl.2005.11.033 Ephrin type-B receptor 4 1
16321531 10.1016/j.bmcl.2005.11.033 Hepatocyte growth factor receptor 1
16321531 10.1016/j.bmcl.2005.11.033 cAMP-dependent protein kinase (PKA) 1
16321531 10.1016/j.bmcl.2005.11.033 Glycogen synthase kinase-3 beta 1
16321531 10.1016/j.bmcl.2005.11.033 RAC-alpha serine/threonine-protein kinase 1
16321531 10.1016/j.bmcl.2005.11.033 Bcr/Abl fusion protein 1
16321531 10.1016/j.bmcl.2005.11.033 Cyclin-dependent kinase 2 1
16321531 10.1016/j.bmcl.2005.11.033 Cyclin-dependent kinase 5 1

Data from ChEMBL 36 via Core Engine