Compound Detail
CHEMBL382774
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Basic Information
| ChEMBL ID | CHEMBL382774 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LADIYNLZGUDYMF-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
369.3
MW (Da)
-1.73
ALogP
7
HBA
4
HBD
164.8
PSA (Ų)
0.44
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas.
Kd 1 meas. best 5.24
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, kainate 5 CHEMBL4041 | Kd | 5.24 | 5.24 | 5800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, kainate 5 | Kd | = | 5800.0 | nM | 5.24 | Antagonist activity against GLUK5-containing kainate receptor by inhibition of k... | 16610801 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16610801 | 10.1021/jm051086f | Glutamate receptor ionotropic, kainate 5 | 1 |
| 16610801 | 10.1021/jm051086f | Glutamate receptor ionotropic, AMPA | 1 |
| 16610801 | 10.1021/jm051086f | Glutamate receptor ionotropic, kainate 2 | 1 |
Data from ChEMBL 36 via Core Engine