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Compound Detail

CHEMBL384576

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CC(C)C[C@@H]1OC(O)=C2C1=NC1=C(C(=O)COC1)[C@H]2c1ccc(F)c(Br)c1

Basic Information

ChEMBL ID CHEMBL384576
Phase Preclinical
Structure Type MOL
InChI Key ZQCQFIFTSDGLPN-JKSUJKDBSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

436.3
MW (Da)
4.19
ALogP
5
HBA
1
HBD
68.1
PSA (Ų)
0.77
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H19BrFNO4
MW 436.28
Aromatic Rings 1
Heavy Atoms 27
NP-Likeness -0.01

Activity Summary

EC50 2 meas. best 7.56

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Sulfonylurea receptor 2, Kir6.2
CHEMBL2095198
EC50 7.56 7.225 27.5 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
17154517 10.1021/jm060549u Sulfonylurea receptor 2, Kir6.2 4

Data from ChEMBL 36 via Core Engine