Compound Detail
CHEMBL385433
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CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Basic Information
| ChEMBL ID | CHEMBL385433 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | CZGUSIXMZVURDU-AEOSSDABSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
1046.2
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 10.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Type-2 angiotensin II receptor CHEMBL4607 | IC50 | 10.1 | 10.1 | 0.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Type-2 angiotensin II receptor | IC50 | = | 0.08 | nM | 10.1 | Displacement of [125I]CGP42112A from human recombinant AT2 receptor expressed in... | 26988801 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 3346871 | 10.1021/jm00398a005 | Rattus norvegicus | 1 |
| 26988801 | 10.1016/j.bmc.2016.03.006 | Type-2 angiotensin II receptor | 1 |
Data from ChEMBL 36 via Core Engine