Compound Detail
CHEMBL38739
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL38739 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WJZHVBZSCOLDKV-YHYXMXQVSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
227.2
MW (Da)
1.35
ALogP
2
HBA
3
HBD
74.0
PSA (Ų)
0.51
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.98
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Interferon-induced, double-stranded RNA-activated protein kinase CHEMBL5785 | IC50 | 4.98 | 4.98 | 10500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Interferon-induced, double-stranded RNA-activated protein kinase | IC50 | = | 10500.0 | nM | 4.98 | Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10... | 21632247 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22077389 | 10.1021/jm201243p | Unchecked | 3 |
| 14998338 | 10.1021/jm030450c | Mus musculus | 2 |
| 21632247 | 10.1016/j.bmcl.2011.04.149 | Interferon-induced, double-stranded RNA-activated protein kinase | 1 |
| 22077389 | 10.1021/jm201243p | Prothrombin | 1 |
| 37348572 | 10.1016/j.bmcl.2023.129383 | Aryl hydrocarbon receptor | 1 |
Data from ChEMBL 36 via Core Engine