Compound Detail
CHEMBL388069
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Basic Information
| ChEMBL ID | CHEMBL388069 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WYDKPFPQRLGAOB-JOCHJYFZSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
418.5
MW (Da)
2.91
ALogP
3
HBA
3
HBD
91.2
PSA (Ų)
0.49
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Somatostatin receptor type 4 CHEMBL1853 | IC50 | 7.12 | 7.12 | 75.0 | 1 |
| Somatostatin receptor type 5 CHEMBL1792 | IC50 | 6.61 | 6.61 | 245.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Somatostatin receptor type 4 | IC50 | = | 75.0 | nM | 7.12 | Displacement of [125I][Leu8-D-Trp22, Tyr25]-SRIF28 from human SST4 receptor | 17559206 |
| Somatostatin receptor type 5 | IC50 | = | 245.0 | nM | 6.61 | Displacement of [125I][Leu8-D-Trp22, Tyr25]-SRIF28 from human SST5 receptor | 17559206 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17559206 | 10.1021/jm070246f | Somatostatin receptor type 1 | 1 |
| 17559206 | 10.1021/jm070246f | Somatostatin receptor type 2 | 1 |
| 17559206 | 10.1021/jm070246f | Somatostatin receptor type 3 | 1 |
| 17559206 | 10.1021/jm070246f | Somatostatin receptor type 4 | 1 |
| 17559206 | 10.1021/jm070246f | Somatostatin receptor type 5 | 1 |
Data from ChEMBL 36 via Core Engine