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Compound Detail

CHEMBL388622

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Clc1ccccc1-c1nc2ccn(Cc3ccc(Br)cc3)cc-2n1

Basic Information

ChEMBL ID CHEMBL388622
Phase Preclinical
Structure Type MOL
InChI Key GUGZWLVFDWQPGU-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

398.7
MW (Da)
5.51
ALogP
3
HBA
0
HBD
30.7
PSA (Ų)
0.46
QED
1
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H13BrClN3
MW 398.69
Aromatic Rings 2
Heavy Atoms 24
NP-Likeness -1.45

Activity Summary

EC50 2 meas. best 6.48

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Bovine viral diarrhea virus 1
CHEMBL612571
EC50 6.48 6.48 330.0 1
Hepatitis C virus
CHEMBL379
EC50 4.6 4.6 25000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
17084081 10.1016/j.bmcl.2006.10.039 ADMET 2
17084081 10.1016/j.bmcl.2006.10.039 Unchecked 2
17084081 10.1016/j.bmcl.2006.10.039 Bovine viral diarrhea virus 1 1
17084081 10.1016/j.bmcl.2006.10.039 Hepatitis C virus 1

Data from ChEMBL 36 via Core Engine