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Compound Detail

CHEMBL3891138

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CCOc1nc2ccc(C(O)(c3ccc(OC)nc3)c3cncs3)cc2c(Cl)c1Cc1ccccc1

Basic Information

ChEMBL ID CHEMBL3891138
Phase Preclinical
Structure Type MOL
InChI Key FNAYGXXYFPNBPF-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

518.0
MW (Da)
6.02
ALogP
7
HBA
1
HBD
77.4
PSA (Ų)
0.27
QED
2
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C28H24ClN3O3S
MW 518.04
Aromatic Rings 5
Heavy Atoms 36
NP-Likeness -0.98

Activity Summary

Kd 2 meas. best 8.57

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Nuclear receptor ROR-gamma
CHEMBL1741186
Kd 8.57 8.57 2.7 1
Unchecked
CHEMBL612545
Kd 8.57 8.57 2.7 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine