Compound Detail
CHEMBL3899584
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Basic Information
| ChEMBL ID | CHEMBL3899584 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FCRODBUNBQJNPU-LEWJYISDSA-N |
1
Targets
1
Activities
1
Assay Types
1
PK Parameters
3
Publications
0
Known Names
Molecular Properties
374.4
MW (Da)
2.15
ALogP
5
HBA
2
HBD
97.9
PSA (Ų)
0.84
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.2
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dipeptidyl peptidase 1 CHEMBL2252 | IC50 | 5.2 | 5.2 | 6309.6 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 50.0 | hr | - |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dipeptidyl peptidase 1 | IC50 | = | 6309.57 | nM | 5.2 | Inhibition of human recombinant DPP1 using Gly-Arg-AMC as substrate preincubated... | 27690432 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27690432 | 10.1021/acs.jmedchem.6b01127 | Dipeptidyl peptidase 1 | 2 |
| 27690432 | 10.1021/acs.jmedchem.6b01127 | No relevant target | 1 |
| 27690432 | 10.1021/acs.jmedchem.6b01127 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine