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Compound Detail

CHEMBL3915197

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COc1ccc(CNC(=O)n2sc3c(ccc[n+]3[O-])c2=O)cc1OC

Basic Information

ChEMBL ID CHEMBL3915197
Phase Preclinical
Structure Type MOL
InChI Key ZKFRYJGIPINGHA-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

361.4
MW (Da)
1.47
ALogP
7
HBA
1
HBD
96.5
PSA (Ų)
0.56
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H15N3O5S
MW 361.38
Aromatic Rings 3
Heavy Atoms 25
NP-Likeness -0.68

Activity Summary

IC50 1 meas. best 6.43

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Protein-glutamine gamma-glutamyltransferase
CHEMBL2730
IC50 6.43 6.43 370.0 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine