Compound Detail
CHEMBL393592
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Basic Information
| ChEMBL ID | CHEMBL393592 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QRCYVFNZAQIPPM-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
514.5
MW (Da)
5.64
ALogP
5
HBA
4
HBD
126.5
PSA (Ų)
0.12
QED
2
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.94
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Urokinase-type plasminogen activator CHEMBL3286 | IC50 | 6.94 | 6.94 | 114.0 | 1 |
| Plasminogen CHEMBL1801 | IC50 | 4.85 | 4.85 | 14000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Urokinase-type plasminogen activator | IC50 | = | 114.0 | nM | 6.94 | Inhibition of human uPA | 18052026 |
| Plasminogen | IC50 | = | 14000.0 | nM | 4.85 | Inhibition of human plasmin | 18052026 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18052026 | 10.1021/jm700962j | Urokinase-type plasminogen activator | 2 |
| 18052026 | 10.1021/jm700962j | Unchecked | 2 |
| 18052026 | 10.1021/jm700962j | Tissue-type plasminogen activator | 1 |
| 18052026 | 10.1021/jm700962j | Plasminogen | 1 |
| 18052026 | 10.1021/jm700962j | Coagulation factor X | 1 |
| 18052026 | 10.1021/jm700962j | Prothrombin | 1 |
Data from ChEMBL 36 via Core Engine