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Compound Detail

CHEMBL394106

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O=C(/C=C/c1ccc(Cl)cc1F)NO

Basic Information

ChEMBL ID CHEMBL394106
Phase Preclinical
Structure Type MOL
InChI Key KXZJNORZIFWCEQ-DUXPYHPUSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

215.6
MW (Da)
2.00
ALogP
2
HBA
2
HBD
49.3
PSA (Ų)
0.45
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C9H7ClFNO2
MW 215.61
Aromatic Rings 1
Heavy Atoms 14
NP-Likeness -1.11

Activity Summary

IC50 1 meas. best 5.36

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
IC50 5.36 5.36 4400.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked IC50 = 4400.0 nM 5.36 Inhibition of Clostridium botulinum A recombinant light chain protease LC/A by F... 17951059

Literature References

PubMed DOI Target Context # Activities
17951059 10.1016/j.bmcl.2007.09.103 Unchecked 1

Data from ChEMBL 36 via Core Engine