Compound Detail
CHEMBL397867
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Basic Information
| ChEMBL ID | CHEMBL397867 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ISZJJLUQBKDSNQ-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
321.4
MW (Da)
1.85
ALogP
3
HBA
1
HBD
66.6
PSA (Ų)
0.82
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 6.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | EC50 | 6.1 | 5.68 | 800.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | EC50 | = | 800.0 | nM | 6.1 | Activation of Mesocestoides corti in TRPM binding site of PZQ expressed in HEK29... | 37970586 |
| Unchecked | EC50 | = | 960.0 | nM | 6.02 | Activation of Echinococcus granulosus in TRPM binding site of PZQ expressed in H... | 37970586 |
| Unchecked | EC50 | = | 12000.0 | nM | 4.92 | Activation of Schistosoma mansoni in TRPM binding site of PZQ expressed in HEK29... | 37970586 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37970586 | 10.1021/acsmedchemlett.3c00350 | Unchecked | 5 |
| 17555960 | 10.1016/j.bmcl.2007.05.063 | Schistosoma mansoni | 4 |
| 37970586 | 10.1021/acsmedchemlett.3c00350 | Schistosoma mansoni | 2 |
| 37970586 | 10.1021/acsmedchemlett.3c00350 | Rodentolepis nana | 1 |
Data from ChEMBL 36 via Core Engine