Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL401032

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
COCCOCc1ccc(-c2cc3onc(-c4ccccc4)c3c(=O)n2C)cc1

Basic Information

ChEMBL ID CHEMBL401032
Phase Preclinical
Structure Type MOL
InChI Key YCAACZFPADQMAR-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
1
PK Parameters
7
Publications
0
Known Names

Molecular Properties

390.4
MW (Da)
4.02
ALogP
6
HBA
0
HBD
66.5
PSA (Ų)
0.45
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H22N2O4
MW 390.44
Aromatic Rings 4
Heavy Atoms 29
NP-Likeness -0.87

Activity Summary

EC50 1 meas. best 8.41

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Nuclear receptor subfamily 4 group A member 2
CHEMBL5002
EC50 8.41 8.41 3.9 1

Pharmacokinetic Data

Parameter Value Units Species
F 95.0 % Mus musculus

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
33289551 10.1021/acs.jmedchem.0c00894 Nuclear receptor subfamily 4 group A member 2 13
33289551 10.1021/acs.jmedchem.0c00894 Unchecked 3
17035009 10.1016/j.bmcl.2006.09.062 Nuclear receptor subfamily 4 group A member 2 2
17035009 10.1016/j.bmcl.2006.09.062 Mus musculus 1
33289551 10.1021/acs.jmedchem.0c00894 SK-N-BE(2) 1
33289551 10.1021/acs.jmedchem.0c00894 PC-12 1
33289551 10.1021/acs.jmedchem.0c00894 HEK-293T 1

Data from ChEMBL 36 via Core Engine