Compound Detail
CHEMBL405821
SENICAPOC 🧪 Phase III
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🧪 Phase III
Basic Information
| ChEMBL ID | CHEMBL405821 |
| Name | SENICAPOC |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | SCTZUZTYRMOMKT-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
4
PK Parameters
20
Publications
3
Known Names
4
Indications
1
Mechanisms
Molecular Properties
323.3
MW (Da)
3.78
ALogP
1
HBA
1
HBD
43.1
PSA (Ų)
0.73
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Intermediate conductance calcium-activated potassium channel protein 4 blocker | BLOCKER | Intermediate conductance calcium-activated potassium channel protein 4 | ✓ | ✓ |
Indications
Anemia, Sickle Cell Asthma Severe Acute Respiratory Syndrome Severe Acute Respiratory Syndrome
Activity Summary
IC50 3 meas. best 8.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Intermediate conductance calcium-activated potassium channel protein 4 CHEMBL4305 | IC50 | 8.22 | 7.0333 | 6.0 | 3 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| Cmax | 1237.09 | nM | Rattus norvegicus |
| F | 51.0 | % | Rattus norvegicus |
| T1/2 | 1.0 | hr | Rattus norvegicus |
| Tmax | 4.0 | hr | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Intermediate conductance calcium-activated potassium channel protein 4 | IC50 | = | 6.0 | nM | 8.22 | Inhibition of Kca 3.1 (unknown origin) | 23121096 |
| Intermediate conductance calcium-activated potassium channel protein 4 | IC50 | = | 12.0 | nM | 7.92 | Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-st... | 18232633 |
| Intermediate conductance calcium-activated potassium channel protein 4 | IC50 | = | 11000.0 | nM | 4.96 | Inhibition of gardos channel (unknown origin) | 23121096 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18232633 | 10.1021/jm070663s | Mus musculus | 6 |
| 18232633 | 10.1021/jm070663s | Rattus norvegicus | 4 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 4 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 23121096 | 10.1021/jm3011433 | Intermediate conductance calcium-activated potassium channel protein 4 | 2 |
| 23121096 | 10.1021/jm3011433 | Sodium channel protein type 3 subunit alpha | 1 |
| 23121096 | 10.1021/jm3011433 | Potassium voltage-gated channel subfamily A member 5 | 1 |
| 23121096 | 10.1021/jm3011433 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 23121096 | 10.1021/jm3011433 | Protein Red | 1 |
| 23121096 | 10.1021/jm3011433 | Sodium channel protein type 1 subunit alpha | 1 |
| 23121096 | 10.1021/jm3011433 | Sodium channel protein type 2 subunit alpha | 1 |
| 18232633 | 10.1021/jm070663s | Liver | 1 |
| 23121096 | 10.1021/jm3011433 | Sodium channel protein type 4 subunit alpha | 1 |
| 23121096 | 10.1021/jm3011433 | Sodium channel protein type 8 subunit alpha | 1 |
| 23121096 | 10.1021/jm3011433 | Sodium channel protein type 9 subunit alpha | 1 |
| 23121096 | 10.1021/jm3011433 | Potassium voltage-gated channel subfamily KQT member 1 | 1 |
| 18232633 | 10.1021/jm070663s | Intermediate conductance calcium-activated potassium channel protein 4 | 1 |
| 18232633 | 10.1021/jm070663s | Cytochrome P450 3A4 | 1 |
Data from ChEMBL 36 via Core Engine