Compound Detail
CHEMBL405888
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Basic Information
| ChEMBL ID | CHEMBL405888 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YGYOXYYVENEFEV-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
2
PK Parameters
3
Publications
0
Known Names
Molecular Properties
421.9
MW (Da)
4.48
ALogP
4
HBA
0
HBD
48.0
PSA (Ų)
0.63
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 6.67
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cannabinoid receptor 1 CHEMBL218 | Ki | 6.67 | 6.67 | 216.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 44.0 | mL.min-1.g-1 | Homo sapiens |
| CL | 388.0 | mL.min-1.g-1 | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cannabinoid receptor 1 | Ki | = | 216.0 | nM | 6.67 | Displacement of [3H]CP-55940 from human CB1R expressed in HEK293 cells | 18335976 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18335976 | 10.1021/jm701487t | Cannabinoid receptor 1 | 2 |
| 18335976 | 10.1021/jm701487t | Liver microsomes | 2 |
| 18335976 | 10.1021/jm701487t | Mus musculus | 1 |
Data from ChEMBL 36 via Core Engine